|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have demonstrated that over expression of TC-1(C8orf4) mRNA occurs in approximately 50% of breast cancer cell lines and primary tumor specimens.
|
17520678 |
2007 |
|
Malignant neoplasm of thyroid
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Thyroid Neoplasm
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Thyroid carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.
|
11056052 |
2000 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have demonstrated that over expression of TC-1(C8orf4) mRNA occurs in approximately 50% of breast cancer cell lines and primary tumor specimens.
|
17520678 |
2007 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, C8orf4 is expressed in most normal colon mucosa samples, and is not expressed in most colon cancer metastases or colon cancer cell lines.
|
15185345 |
2004 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The Cancer Genome Atlas genomics data also confirmed that the mRNA expression of C8orf4 was positively associated with the copy number alteration of C8orf4 (correlation coefficient = 0.213, P < .001), and negatively correlated with the methylation level of C8orf4 (correlation coefficient = -0.408, P < .001).
|
31374065 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue.
|
25869879 |
2015 |
|
Vitamin B 12 Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
They also add new approaches to studying mild and severe TC I deficiency and to reducing confusion of its low cobalamin levels with those of cobalamin deficiency and its often dramatically different prognosis and management.
|
19686235 |
2009 |
|
Malignant neoplasm of colon stage IV
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.
|
15185345 |
2004 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The methylation level of C8orf4 is decreased in CSCCs and is responsible for the increased expression of C8orf4.
|
31374065 |
2019 |
|
Squamous intraepithelial lesion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
C8orf4 expression was positively correlated with the poor differentiation of CSCCs (P = .009), and with aberrant expression of β-catenin in CSCCs (P = .002) and squamous intraepithelial lesions (P < .001).
|
31374065 |
2019 |
|
High-Grade Squamous Intraepithelial Lesions
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, the expressions of C8orf4 and β-catenin were synergistically increased in CSCCs and HSILs and higher than those in LSILs and normal cervical tissues.
|
31374065 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The TC-1 protein expression also showed significant associations with TNM stage, pathological grade, and lymph node metastasis of patients (p<0.05).
|
31081098 |
2019 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the expressions of C8orf4 and β-catenin were synergistically increased in CSCCs and HSILs and higher than those in LSILs and normal cervical tissues.
|
31374065 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The Cancer Genome Atlas genomics data also confirmed that the mRNA expression of C8orf4 was positively associated with the copy number alteration of C8orf4 (correlation coefficient = 0.213, P < .001), and negatively correlated with the methylation level of C8orf4 (correlation coefficient = -0.408, P < .001).
|
31374065 |
2019 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways.
|
17520678 |
2007 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, C8orf4 is expressed in most normal colon mucosa samples, and is not expressed in most colon cancer metastases or colon cancer cell lines.
|
15185345 |
2004 |
|
Pulmonary Fibrosis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.
|
26744410 |
2016 |
|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid cancer 1, in intratumoral activated CD8<sup>+</sup> T cells in a murine hepatocellular carcinoma (HCC) implantation model.
|
28382040 |
2017 |
|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
C8orf4 is located in the cytoplasm of HCC tumour cells and associates with the NOTCH2 intracellular domain, which impedes the nuclear translocation of N2ICD.
|
25985737 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, LSM1, BAG4, and C8orf4 are breast cancer oncogenes that can work in combination to influence the transformed phenotype in human mammary epithelial cells.
|
17178857 |
2006 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The thyroid cancer-1 (TC-1) or c8orf4 gene encodes a 106-residue naturally disordered protein that has been found to be associated with thyroid, gastric, and breast cancer.
|
23880650 |
2013 |